Peer-reviewed veterinary case report
High blood pressure linked to kidney damage in dogs with kidney
By Finco, Delmar R·Published in Journal of veterinary internal medicine·2004·Department of Physiology and Pharmacology, United States·View original on PubMed →
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Original publication title: Association of systemic hypertension with renal injury in dogs with induced renal failure.
- Species:
- dog
Plain-English summary
A group of dogs with surgically induced kidney failure were studied to see if high blood pressure (hypertension) caused further kidney damage. The researchers found that dogs with higher blood pressure had worse kidney function and more signs of injury over time compared to those with lower blood pressure. Specifically, the dogs with higher blood pressure had lower kidney filtration rates and higher levels of protein in their urine, indicating more severe kidney problems. This suggests that managing blood pressure could be important for dogs with kidney issues.
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Abstract
Systemic hypertension is hypothesized to cause renal injury to dogs. This study was performed on dogs with surgically induced renal failure to determine whether hypertension was associated with altered renal function or morphology. Mean arterial pressure (MAP), heart rate (HR), systolic arterial pressure (SAP), and diastolic arterial pressure (DAP) were measured before and after surgery. Glomerular filtration rate (GFR) and urine protein:creatinine ratios (UPC) were measured at 1, 12, 24, 36, and 56-69 weeks after surgery, and renal histology was evaluated terminally. The mean of weekly MAP, SAP, and DAP measurements for each dog over the 1st 26 weeks was used to rank dogs on the basis of MAP, SAP, or DAP values. A statistically significant association was found between systemic arterial pressure ranking and ranked measures of adverse renal responses. When dogs were divided into higher pressure and lower pressure groups on the basis of SAP, group 1 (higher pressure, n = 9) compared with group 2 (lower pressure, n = 10) had significantly lower GFR values at 36 and 56-69 weeks; higher UPC values at 12 and 56-69 weeks; and higher kidney lesion scores for mesangial matrix, tubule damage, and fibrosis. When dogs were divided on MAP and DAP values, group 1 compared with group 2 had significantly lower GFR values at 12, 24, 36, and 56-69 weeks; higher UPC values at 12 and 56-69 weeks; and higher kidney lesion scores for mesangial matrix, tubule damage, fibrosis, and cell infiltrate. These results demonstrate an association between increased systemic arterial pressure and renal injury. Results from this study might apply to dogs with some types of naturally occurring renal failure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15188813/