Peer-reviewed veterinary case report
Vitamin D and hormone changes in dogs with chronic kidney disease
By Parker, V J et al.·Published in Journal of veterinary internal medicine·2017·The Ohio State University, United States·View original on PubMed →
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Original publication title: Association of Vitamin D Metabolites with Parathyroid Hormone, Fibroblast Growth Factor-23, Calcium, and Phosphorus in Dogs with Various Stages of Chronic Kidney Disease.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease (CKD) showed lower levels of vitamin D compared to healthy dogs, especially in the later stages of the disease. This decrease in vitamin D was linked to higher levels of parathyroid hormone and other factors that can worsen kidney health. Understanding these changes in vitamin D could help veterinarians manage CKD more effectively and improve outcomes for affected dogs.
People also search for: dog kidney disease symptoms · vitamin D for dogs with kidney disease · chronic kidney disease treatment in dogs
Abstract
BACKGROUND: Hypovitaminosis D is associated with progression of renal disease, development of renal secondary hyperparathyroidism (RHPT), chronic kidney disease-mineral bone disorder (CKD-MBD), and increased mortality in people with CKD. Despite what is known regarding vitamin D dysregulation in humans with CKD, little is known about vitamin D metabolism in dogs with CKD. OBJECTIVES: The purpose of our study was to further elucidate vitamin D status in dogs with different stages of CKD and to relate it to factors that affect the development of CKD-MBD, including parathyroid hormone (PTH), fibroblast growth factor-23 (FGF-23), calcium, and phosphorus concentrations. METHODS: Thirty-seven dogs with naturally occurring CKD were compared to 10 healthy dogs. Serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)D], and 24,25-dihydroxyvitamin D [24,25(OH)D], and PTH and FGF-23 concentrations were measured. Their association with serum calcium and phosphorus concentrations and IRIS stage was determined. RESULTS: Compared to healthy dogs, all vitamin D metabolite concentrations were significantly lower in dogs with International Renal Interest Society (IRIS) stages 3 and 4 CKD (r [creatinine]: -0.49 to -0.60; P < .05) but not different in dogs with stages 1 and 2 CKD. All vitamin D metabolites were negatively correlated with PTH, FGF-23, and phosphorus concentrations (r: -0.39 to -0.64; P < .01). CONCLUSIONS AND CLINICAL IMPORTANCE: CKD in dogs is associated with decreases in all vitamin D metabolites evaluated suggesting that multiple mechanisms, in addition to decreased renal mass, affect their metabolism. This information could have prognostic and therapeutic implications.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28186657/