Peer-reviewed veterinary case report
Environment and health links to T-zone lymphoma in older Golden
By Labadie, Julia D et al.·Published in Journal of veterinary internal medicine·2019·Department of Microbiology, United States·View original on PubMed →
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Original publication title: Associations of environment, health history, T-zone lymphoma, and T-zone-like cells of undetermined significance: A case-control study of aged Golden Retrievers.
- Species:
- dog
Plain-English summary
A group of older Golden Retrievers with T-zone lymphoma (a type of cancer) was studied to understand what factors might be linked to this disease. The research found that dogs with hypothyroidism or those that had mange were more likely to develop T-zone lymphoma, while omega-3 supplements seemed to lower the risk. Additionally, bladder infections and eye problems were common in both dogs with T-zone lymphoma and those with similar but less serious cells. These findings suggest that certain health issues may increase the risk of T-zone lymphoma, and more research is needed on the benefits of omega-3 supplements for these dogs.
People also search for: Golden Retriever T-zone lymphoma symptoms · omega-3 supplements for dogs · bladder infection in dogs · eye disease in Golden Retrievers
Abstract
BACKGROUND: T-zone lymphoma (TZL), an indolent disease in older dogs, comprises approximately 12% of lymphomas in dogs. TZL cells exhibit an activated phenotype, indicating the disease may be antigen-driven. Prior research found that asymptomatic aged Golden Retrievers (GLDRs) commonly have populations of T-zone-like cells (phenotypically identical to TZL) of undetermined significance (TZUS). OBJECTIVE: To evaluate associations of inflammatory conditions, TZL and TZUS, using a case-control study of GLDRs. ANIMALS: TZL cases (n = 140), flow cytometrically diagnosed, were identified through Colorado State University's Clinical Immunology Laboratory. Non-TZL dogs, recruited through either a database of owners interested in research participation or the submitting clinics of TZL cases, were subsequently flow cytometrically classified as TZUS (n = 221) or control (n = 147). METHODS: Health history, signalment, environmental, and lifestyle factors were obtained from owner-completed questionnaires. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using multivariable logistic regression, obtaining separate estimates for TZL and TZUS (versus controls). RESULTS: Hypothyroidism (OR, 0.3; 95% CI, 0.1-0.7), omega-3 supplementation (OR, 0.3; 95% CI, 0.1-0.6), and mange (OR, 5.5; 95% CI, 1.4-21.1) were significantly associated with TZL. Gastrointestinal disease (OR, 2.4; 95% CI, 0.98-5.8) had nonsignificantly increased TZL odds. Two shared associations for TZL and TZUS were identified: bladder infection or calculi (TZL OR, 3.5; 95% CI, 0.96-12.7; TZUS OR, 5.1; 95% CI, 1.9-13.7) and eye disease (TZL OR, 2.3; 95% CI, 0.97-5.2; TZUS OR, 1.9; 95% CI, 0.99-3.8). CONCLUSIONS AND CLINICAL IMPORTANCE: These findings may elucidate pathways involved in TZUS risk and progression from TZUS to TZL. Further investigation into the protective association of omega-3 supplements is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30666722/