Peer-reviewed veterinary case report
Ascorbic acid reduces kidney injury after dog kidney transplant
By Lee, Jae-il et al.·Published in Journal of veterinary science·2006·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation.
- Species:
- dog
Plain-English summary
A group of eight beagle dogs underwent kidney transplantation and were given ascorbic acid to see if it could help reduce damage from the surgery. After the procedure, tests showed that the dogs receiving ascorbic acid had better kidney function and less tissue damage compared to those who did not receive it. The study suggests that ascorbic acid may help protect the kidneys during recovery from surgery.
People also search for: dog kidney transplant recovery · ascorbic acid for dogs · beagle kidney function test
Abstract
This study examined the effects of ascorbic acid on the attenuation of an ischemia-reperfusion (I/R) injury after a canine renal transplantation. Eight beagle dogs were subjected to a renal auto-transplantation followed by the administration of ascorbic acid (treatment group) and the same amount of vehicle (physiological saline, control group). Blood samples were collected from these dogs to perform the kidney function tests and the invasive blood pressure was measured in the renal artery at pre- and post-anastomosis. The antioxidant enzymes of level 72 h after the transplant were measured. The kidneys were taken for a histopathology evaluation at day 21. The kidney function tests showed a significant difference between the control and treatment group. The invasive blood pressure in the renal artery was similar in the groups. The activity of the antioxidant enzymes in the blood plasma was significant lower in the control group than in the treatment group. The histopathology findings revealed the treatment group to have less damage than the control group. The results of this study suggest that ascorbic acid alone might play a role in attenuating I/R injury and assist in the recovery of the renal function in a renal transplantation model.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17106230/