Peer-reviewed veterinary case report
Dog with autoimmune hemolytic anemia and red blood cell protein
By Tsuchida, S et al.·Published in The Journal of veterinary medical science·1991·Department of Legal Medicine and Human Genetics, Japan·View original on PubMed →
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Original publication title: Autoantibodies and red blood cell membrane proteins in a case of canine autoimmune hemolytic anemia.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog was diagnosed with autoimmune hemolytic anemia (AIHA), a condition where the dog's immune system attacks its own red blood cells, leading to anemia. During a crisis phase, tests showed that the dog's blood had autoantibodies, which are proteins that mistakenly target its own cells. After treatment, the dog's condition improved, and it entered a remission phase, showing changes in certain blood proteins but no changes in blood type. This indicates that while the immune response was altered, the dog's overall health improved with appropriate care.
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Abstract
Autoantibodies and erythrocyte membrane proteins were analyzed in a case of a dog with autoimmune hemolytic anemia (AIHA). In crisis phase, antiglobulin test was positive. The eluate from the erythrocytes of the dog with AIHA gave agglutination against autologus erythrocytes. Immunoglobulin subclasses in the eluate were revealed to be IgG and IgA by the double diffusion test. Comparing the SDS polyacrylamide gel electrophoretic patterns of erythrocyte membrane proteins between the crisis and remission phases, there was a change in the protein on protein 4.1 region. However, there were no changes in blood group typings in two phases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1830775/