Peer-reviewed veterinary case report
Dog with no brain ventricles and holoprosencephaly causing seizures
By Barnard, Laura et al.·Published in Journal of veterinary internal medicine·2020·Canada West Veterinary Specialists, Canada·View original on PubMed →
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Original publication title: Aventriculi associated with holoprosencephaly in a dog.
- Species:
- dog
Plain-English summary
A 10-month-old neutered male mixed breed dog was brought in for poorly controlled seizures. Imaging tests showed that he was missing key parts of his brain's ventricular system, which are normally filled with fluid. After further examination, the vet diagnosed him with a rare brain condition called lobar holoprosencephaly, which is a congenital malformation. Unfortunately, this condition is serious and can lead to significant neurological issues.
People also search for: dog seizures treatment · mixed breed dog brain problems · congenital brain malformation in dogs
Abstract
CASE DESCRIPTION: A 10-month-old neutered male mixed breed dog was presented for assessment of poorly controlled seizures. CLINICAL FINDINGS: Magnetic resonance imaging of the brain disclosed complete absence of the lateral and third ventricles and mesencephalic aqueduct. Postmortem computed tomographic (CT) imaging and positive contrast cisterno-ventriculography confirmed the lack of a contiguous ventricular system. However, histopathology identified the presence of vestigial lateral and third ventricles with hypoplastic choroid plexus, atresia of the third ventricle, and fused thalami, consistent with a diagnosis of lobar holoprosencephaly (HPE). CLINICAL RELEVANCE: To our knowledge, this report is the first case of radiographically confirmed aventriculi associated with HPE, a rare congenital malformation previously reported in people, to be described in veterinary medicine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33009835/