Peer-reviewed veterinary case report
Dog with no brain ventricles linked to holoprosencephaly brain defect
By Laura Barnard et al.·Published in Journal of Veterinary Internal Medicine·2020·View original on Semantic Scholar →
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Original publication title: Aventriculi associated with holoprosencephaly in a dog
- Species:
- dog
Plain-English summary
A 10-month-old neutered male mixed breed dog was brought in for poorly controlled seizures. Imaging tests showed that he was missing key parts of his brain's ventricular system, which are normally responsible for producing and circulating cerebrospinal fluid. Despite the unusual findings, the dog was diagnosed with a rare congenital condition called holoprosencephaly, which affects brain development. Unfortunately, the condition is serious and can lead to ongoing health issues.
People also search for: dog seizures treatment · mixed breed dog brain problems · what is holoprosencephaly in dogs
Abstract
Abstract Case Description A 10‐month‐old neutered male mixed breed dog was presented for assessment of poorly controlled seizures. Clinical Findings Magnetic resonance imaging of the brain disclosed complete absence of the lateral and third ventricles and mesencephalic aqueduct. Postmortem computed tomographic (CT) imaging and positive contrast cisterno‐ventriculography confirmed the lack of a contiguous ventricular system. However, histopathology identified the presence of vestigial lateral and third ventricles with hypoplastic choroid plexus, atresia of the third ventricle, and fused thalami, consistent with a diagnosis of lobar holoprosencephaly (HPE). Clinical Relevance To our knowledge, this report is the first case of radiographically confirmed aventriculi associated with HPE, a rare congenital malformation previously reported in people, to be described in veterinary medicine.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/33009835