Peer-reviewed veterinary case report
Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia.
- Journal:
- Behavioural brain research
- Year:
- 2011
- Authors:
- Wolff, Amy R et al.
- Affiliation:
- Psychology Department
- Species:
- rodent
Abstract
Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21816179/