Peer-reviewed veterinary case report
The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss.
- Journal:
- Behavioural brain research
- Year:
- 2010
- Authors:
- Wolff, Amy R & Bilkey, David K
- Affiliation:
- Psychology Department
- Species:
- rodent
Abstract
The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20471999/