Peer-reviewed veterinary case report
Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease.
- Journal:
- Chemical communications (Cambridge, England)
- Year:
- 2023
- Authors:
- Kato, Izumi et al.
- Affiliation:
- Faculty of Pharmaceutical Sciences · Japan
Abstract
A new compound, a derivative of 3,4,5-trimethoxy--phenyl benzamide bearing an 8''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects, indicating high potential as a therapeutic drug for Parkinson's disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37753573/