Polyfunctionalized-Arylsulfonyl Indoles: Identification of ()--Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-Based Therapy of Parkinson's Disease.

Abstract

Herein, we have identified the polyfunctionalized 1-(phenylsulfonyl)-1-indole-2-carboxylic acid derivative MTP150 for the treatment of neurodegenerative diseases owing to its efficacy in reducing protein aggregation, modulating matrix metalloproteinase activity, mitigating neuroinflammation, and enhancing DNA damage repair pathways across in vivomodels of Alzheimer's disease, Parkinson's disease (PD), and Huntington's disease. Further experiments in an in vivomodel of PD showed that MTP150 increased motor performance, reduced oxidative stress levels, and restored mitochondrial function in model flies. In addition, MTP150 exhibited neuroprotective effects in PD model cells, thereby supporting its therapeutic potential for this disease.