Peer-reviewed veterinary case report
Dog with epilepsy had brain malformation and severe brain inflammation
By Klang, A et al.·Published in Journal of comparative pathology·2014·Institute of Pathology and Forensic Veterinary Medicine·View original on PubMed →
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Original publication title: Bilateral hippocampal malformation and concurrent granulomatous meningoencephalitis in a dog with refractory epilepsy.
- Species:
- dog
Plain-English summary
A 5-year-old dog was brought to the vet after showing signs of not eating and being unusually tired for three weeks, along with experiencing severe seizures. Despite trying various anti-seizure medications, the dog's condition did not improve, and sadly, the decision was made to humanely euthanize the pet ten weeks later. A closer examination of the dog's brain revealed serious malformations and inflammation that contributed to the ongoing seizures. Unfortunately, this case highlights a rare brain issue that can lead to severe epilepsy in dogs.
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Abstract
A 5-year-old dog was referred with a history of anorexia and apathy for 3 weeks and acute status epilepticus. Ten weeks later the animal was humanely destroyed due to refractory epilepsy despite anti-epileptic medical treatment. Microscopical examination of the brain revealed bilateral malformation of the dentate gyrus with abnormal gyration. Cornu ammonis segments comprised of sparse pyramidal cells accompanied by marked gliosis. Additionally, there was severe generalized disseminated granulomatous meningoencephalitis, mainly localized to the white matter of the cerebral hemispheres. This is the first description of bilateral hippocampal malformation in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24461687/