Peer-reviewed veterinary case report
Dog with kidney failure found to have rare xanthine stones in both
By Kucera, J et al.·Published in The Journal of small animal practice·1997·Clinic of Small Animal Internal Medicine·View original on PubMed →
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Original publication title: Bilateral xanthine nephrolithiasis in a dog.
- Species:
- dog
Plain-English summary
A 4-year-old female dachshund was brought in showing signs of severe kidney failure, which included lethargy and decreased appetite. Tests revealed that she had a rare condition called xanthinuria, leading to the formation of xanthine stones in her kidneys. Unfortunately, the dog's kidneys were severely damaged, and she did not survive. This case highlights the importance of recognizing metabolic disorders that can lead to kidney problems in dogs.
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Abstract
Xanthinuria is an uncommon metabolic disorder clinically manifested as urolithiasis. There are two forms of the disease, congenital and iatrogenic. The former was diagnosed in a four-year-old dachshund bitch. The patient was presented with signs of terminal chronic renal failure. Urine was bacteriologically sterile with massive amorphous crystalluria. Bilateral nephrolithiasis was diagnosed at necropsy. The kidneys were shrunken with marked atrophy of the renal cortex and medulla. Infrared spectrometry revealed that the stones comprised 100 per cent xanthine. Later, two of the patient's siblings were examined for urine xanthine content; both showed higher concentrations of xanthine than a control dog. The described case is compared with seven known published cases of congenital xanthinuria.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9239633/