Peer-reviewed veterinary case report
Canine jaw bone cancer survival and spread after surgery study
By Coyle, V J et al.·Published in Veterinary and comparative oncology·2015·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007).
- Species:
- dog
Plain-English summary
A group of dogs with jaw tumors called osteosarcoma underwent surgery to remove the affected part of the jaw. Out of 50 dogs studied, 21 received chemotherapy after surgery. Unfortunately, more than half of the dogs developed metastasis (cancer spread), with those having lower-grade tumors showing better survival rates. The study found that dogs with lower-grade tumors and those who received chemotherapy had a better chance of living longer and staying free of metastasis.
People also search for: dog jaw tumor treatment · canine osteosarcoma prognosis · chemotherapy for dog cancer
Abstract
The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours (P = 0.002); and 5/21 (24%) dogs with grade II/III tumours alive versus 17/22 (77%) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23410097/