Peer-reviewed veterinary case report
Early kidney disease markers in dogs compared: SDMA and cystatin C
By Kim, Joonyoung et al.·Published in The Journal of veterinary medical science·2020·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Biomarkers for chronic kidney disease in dogs: a comparison study.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease (CKD) were tested to see if certain blood markers could help detect early kidney problems. Researchers found that levels of cystatin C (CysC) were significantly higher in dogs with CKD compared to healthy dogs, and this marker was particularly good at identifying the earliest stages of kidney disease. This means that measuring CysC could help veterinarians catch kidney issues sooner, allowing for earlier treatment. The study suggests that using CysC levels could improve how we diagnose and manage kidney disease in dogs.
People also search for: dog kidney disease symptoms · early signs of kidney disease in dogs · cystatin C test for dogs
Abstract
The aim of this study was to determine whether serum symmetric dimethylarginine (SDMA) and cystatin C (CysC) levels can be utilized as more accurate markers of early kidney dysfunction in dogs. Forty-one client-owned dogs with chronic kidney disease (CKD), which were clinically stable, and ten beagles as healthy controls were included. All dogs underwent physical examination, systemic blood pressure measurement, complete blood cell count, and plasma biochemistry analyses. Frozen serum was used for SDMA and CysC analyses. Data analysis was performed using Kruskal Wallis, Pearson's correlation, Bland-Altman plots, and receiver operating characteristic curve. SDMA and CysC levels were significantly higher in patients with CKD at various International Renal Interest Society (IRIS) stages than in the healthy controls. In particular, CysC level was the only biomarker that could indicate the earliest stage of CKD (IRIS stage I). Similar to these results, CysC level showed better sensitivity and specificity compared to the other biomarkers in early CKD dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32581150/