Peer-reviewed veterinary case report
Biphenotypic B-cell lymphoma causing skin masses and kidney bleeding
By Granum, Liana et al.·Published in Veterinary Clinical Pathology·2015·College of Veterinary Medicine Oregon State University Corvallis OR USA, United States·View original on Crossref →
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Original publication title: Biphenotypic B‐cell lymphoma in 2 cats
- Species:
- cat
Plain-English summary
A 5-year-old male domestic shorthair cat was brought in with multiple lumps on its thigh, while a 7-year-old male cat showed signs of lethargy due to bleeding from a kidney affected by cancer. Tests confirmed both cats had a type of cancer called biphenotypic B-cell lymphoma, which means the cancer cells showed characteristics of both B- and T-cells. Unfortunately, both cats experienced rapid disease progression after diagnosis, indicating a poor prognosis. Treatment options for this type of lymphoma can be limited, and it’s essential for pet owners to discuss the best approach with their veterinarian.
People also search for: cat lumps on thigh · cat lethargy kidney cancer · biphenotypic lymphoma in cats treatment
Abstract
AbstractThe clinical and pathologic features of biphenotypic B‐cell lymphoma in 2 cats are reported. Clinical presentation varied from multiple cutaneous masses identified on the thigh in one cat to signs of lethargy from acute hemorrhage due to neoplastic infiltration of one kidney in the other. Cytology and histopathology confirmed round cell neoplasia in both cats and immunochemical staining demonstrated expression of both B‐ and T‐lymphocyte markers by the neoplastic cells in both animals. InPCRanalysis of antigen receptor gene rearrangement, clonal rearrangement of B‐cell receptor genes and polyclonal T‐cell receptor gene rearrangement were demonstrated in both lymphomas. These findings were consistent with a diagnosis of B‐cell lymphoma with aberrant CD3 expression in both cases. Clinical progression of disease post diagnosis was rapid in both cats, suggesting a poor prognosis for this lymphoma type. Although bigenotypic receptor rearrangement of lymphoma cells appears relatively common, this is the first known report of actual biphenotypic lymphoma in cats.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vcp.12251