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Peer-reviewed veterinary case report

Bleeding in Quarter Horse filly - what is von Willebrand disease?

By Brooks, M et al.·Published in Journal of the American Veterinary Medical Association·1991·New York State Department of Health, United States·View original on PubMed

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Original publication title: Bleeding disorder (von Willebrand disease) in a quarter horse.

Species:
horse

Plain-English summary

A Quarter Horse filly was brought in for bleeding problems, which were mainly noticed after injuries and from her mouth and nose. Tests showed she had von Willebrand disease, a bleeding disorder caused by a deficiency in a specific protein that helps blood clot. This condition is similar to what is seen in humans. With the right tests, veterinarians can now diagnose this disease in horses, allowing for better management of their bleeding issues.

People also search for: Quarter Horse bleeding disorder · von Willebrand disease in horses · horse nose bleeding treatment

Abstract

Bleeding diathesis in a Quarter Horse filly was caused by von Willebrand disease. Hemorrhage occurred mainly from mucosal surfaces and after trauma. Quantitative and qualitative measurements of plasma von Willebrand factor (vWF) documented a specific deficiency of vWF high molecular weight multimers, and concurrently greater than expected deficiency of vWF activity relative to vWF concentration. These findings are characteristic of type-II von Willebrand disease in human beings. Application of vWF assays used in human and small animal medicine now permits evaluation of vWF and diagnosis of von Willebrand disease in horses with bleeding disorders.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1995565/