Peer-reviewed veterinary case report
Hemophilia A in two related quarter horse colts.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 1988
- Authors:
- Henninger, R W
- Affiliation:
- South Plains Veterinary Clinic
- Species:
- horse
Plain-English summary
Two related Quarter Horse colts were diagnosed with hemophilia A, a condition that affects their blood's ability to clot due to a lack of a specific factor (factor VIII:C). One colt showed signs of trouble breathing and difficulty swallowing because of a blood clot in the neck area, while the other colt suffered from internal bleeding that ultimately led to its death. Tests confirmed the diagnosis by showing abnormal blood clotting results. Hemophilia A is passed down through the X chromosome. Unfortunately, the treatment did not save the second colt, and the first colt's condition was serious.
Abstract
Severe hemorrhagic diathesis caused by hemophilia A (factor VIII:C deficiency) was diagnosed in 2 related Quarter Horse colts. Clinical signs consisted of dyspnea and dysphagia attributable to cranial cervical hematoma in one colt and to intra-abdominal hemorrhage resulting in death of the second colt. Factor VIII:C deficiency, a defect of the intrinsic coagulation pathway, is suggested by results of coagulation studies--prolonged activated partial thromboplastin time, normal prothrombin time, and normal primary bleeding time. The diagnosis was confirmed by results of factor VIII:C assays. Hemophilia A is inherited as an X chromosome-linked trait.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/3138224/