Peer-reviewed veterinary case report
Blood lymphocyte subsets in canine idiopathic pericardial effusion.
- Journal:
- Veterinary immunology and immunopathology
- Year:
- 2004
- Authors:
- Guglielmino, R et al.
- Affiliation:
- Department of Animal Pathology · Italy
- Species:
- dog
Abstract
The immunophenotype of peripheral blood lymphocytes was investigated in 23 dogs diagnosed with idiopathic pericardial effusion in order to provide information about a possible role of the immune system in this pathology. Flow cytometric analysis showed a significant reduction in nearly all lymphocyte subsets examined and a strong, significant (P < 0.001) reduction of the CD4 subset, which gave rise to a significantly lower CD4/CD8 ratio. Our data suggest that an imbalance in the immune system is present during the course of the disease, preferentially affecting the T helper cell response.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15010225/