Peer-reviewed veterinary case report
Lymphocyte types in dogs with low white blood cells
By Hamouzová, Pavla et al.·Published in Veterinary immunology and immunopathology·2023·Department of Physiology·View original on PubMed →
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Original publication title: Lymphocyte immunophenotyping in dogs with lymphopenia of common causes.
- Species:
- dog
Plain-English summary
A group of dogs with low lymphocyte levels (lymphopenia) was studied to understand the causes and effects on their immune system. Most of the affected dogs were older than 7 years, with many cases linked to recent surgeries or inflammatory diseases, particularly in the gastrointestinal tract. Blood tests showed that these dogs often had increased levels of C-reactive protein (CRP), indicating inflammation, and a lower percentage of T lymphocytes, which are important for immune function. Understanding these patterns can help veterinarians better assess and treat dogs with lymphopenia.
People also search for: dog lymphopenia causes · older dog immune system issues · lymphocyte levels in dogs · dog inflammatory disease symptoms
Abstract
Lymphocyte immunophenotyping can be useful for evaluating immune competence and predicting the disease prognosis. It is essential to gain knowledge about canine lymphocyte immunophenotypes in various conditions. The study deals with the characteristics of lymphopenia in dogs, with an emphasis on lymphocyte immunophenotyping by flow cytometry. Blood samples from 44 dogs with lymphopenia were included in the study. All lymphopenias sent from veterinary clinics to the diagnostic laboratory were analyzed. The hematological and biochemical abnormalities were investigated, as well as the effect of the age. Lymphopenias were classified according to the level of C-reactive protein (CRP). The percentage of T cells, B cells, Tcells and Tcells, and T/B and T/Tratios were determined by flow cytometry. Lymphopenias often occurred in dogs over 7 years of age (79.5 %). The most common were postoperative lymphopenia (31.8 %) and inflammatory diseases (29.5 %), most commonly affecting the gastrointestinal tract. Frequent abnormalities were monocytosis (56.8 %), increased CRP (72.7 %) and decreased albumin/globulin ratio (50.0 %). The percentage of Tlymphocytes was significantly lower in the group with elevated CRP than in the group with basal CRP (P = 0.0329). A negative correlation was found between the level of CRP and the percentage of Tlymphocytes (r = -0.3278, P = 0.0390). This study provided new insights into the appearance, incidence and classification of canine lymphopenia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37331238/