Peer-reviewed veterinary case report
Blood vitamin changes in dogs with chronic kidney disease
By Galler, A et al.·Published in Veterinary journal (London, England : 1997)·2012·Department for Companion Animals and Horses·View original on PubMed →
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Original publication title: Blood vitamin levels in dogs with chronic kidney disease.
- Species:
- dog
Plain-English summary
A group of 19 dogs with chronic kidney disease (CKD) had their blood vitamin levels tested to see how the disease affected their vitamin metabolism. The results showed that these dogs had higher levels of certain vitamins like A, C, and B vitamins compared to healthy dogs, but lower levels of vitamin D and folate. While some vitamins were found in higher amounts, the lower vitamin D and folate levels might need further investigation to determine if supplements could help these dogs.
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Abstract
Chronic kidney disease (CKD) may affect excretion and metabolism of vitamins but data for dogs are limited. In this study, blood vitamin levels were investigated in 19 dogs with chronic renal failure. High performance liquid chromatography was used to quantify retinol, retinyl esters, tocopherol, thiamine, riboflavin, pyridoxal-5'-phosphate, ascorbic acid and 25-hydroxycholecalciferol concentrations, whereas cobalamin, folate, biotin and pantothenic acid were measured by microbiological methods. Levels of retinol, retinyl palmitate, ascorbic acid, and vitamins B1, B2 and B6 were increased compared to healthy dogs. Dogs with CKD showed decreased concentrations of 25-hydroxycholecalciferol and folate. Alpha-tocopherol, biotin, pantothenate and cobalamin levels were not significantly different between controls and dogs with CKD. Whether lower vitamin D and folate concentrations in dogs with CKD justify supplementation has to be evaluated in future studies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21767966/