Peer-reviewed veterinary case report
Dog developed low bone marrow after fenbendazole treatment
By Gary, Anthony T et al.·Published in Journal of the American Animal Hospital Association·2004·Department of Veterinary Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Bone marrow hypoplasia associated with fenbendazole administration in a dog.
- Species:
- dog
Plain-English summary
A 1.5-year-old Doberman Pinscher developed a sudden fever and seemed very unwell after starting fenbendazole, a medication for a suspected lungworm infection. Blood tests showed low levels of red and white blood cells, and a bone marrow sample indicated a condition called bone marrow hypoplasia, where the marrow isn't producing enough blood cells. After stopping the fenbendazole and providing antibiotics and fluids, the dog's symptoms and blood counts returned to normal within 15 days. It appears the dog had an unusual reaction to the medication.
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Abstract
A 1.5-year-old Doberman pinscher was presented with sudden-onset of fever and malaise. Twelve days prior to presentation, fenbendazole therapy was initiated for a suspected lungworm infection. Results of a complete blood count on presentation showed pancytopenia, while histopathological evaluation of a bone marrow core sample revealed bone marrow hypoplasia of undetermined etiology. Bactericidal antibiotics and fluid therapy, as well as discontinuation of fenbendazole administration, led to a complete resolution of clinical and hematological abnormalities within 15 days. An idiosyncratic reaction to fenbendazole was suspected based on the absence of infectious, neoplastic, autoimmune, and toxic etiologies, as well as resolution of clinical signs and pancytopenia upon drug withdrawal.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15131104/