Peer-reviewed veterinary case report
Brain and eye tumors from venereal cancer in a dog
By Ferreira, A J et al.·Published in The Journal of small animal practice·2000·CIISA-Serviç·View original on PubMed →
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Original publication title: Brain and ocular metastases from a transmissible venereal tumour in a dog.
- Species:
- dog
Plain-English summary
A five-year-old crossbred dog developed rapidly growing lumps on its penis and lymph node, along with severe eye problems like squinting and redness. The vet diagnosed transmissible venereal tumor (TVT) and started chemotherapy with vincristine and prednisolone, which initially helped the dog recover. Unfortunately, the dog later relapsed with new symptoms, including seizures and a mass in the eye. After a CT scan showed brain tumors, the owners chose to euthanize the dog due to the poor prognosis.
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Abstract
A five-year-old crossbred dog was referred with rapidly growing masses over its penis and right popliteal lymph node. The dog had severe blepharospasm, congestion of episcleral vessels and rubeosis iridis of the left eye. A presumptive diagnosis of transmissible venereal tumour (TVT) and iridocyclitis was made based on the results of fine needle aspiration. Chemotherapy with vincristine and prednisolone was initiated and after four months the dog made a complete recovery. However, the dog subsequently relapsed, showing miosis, blepharospasm and a well defined mass within the anterior chamber of the left eye. In addition, the dog exhibited generalised 'grand mal' type seizures. Computed tomographic (CT) examination of the brain revealed two distinct masses in the left frontal lobe. Because of the poor prognosis, the owners elected to have the dog euthanased. On histopathology, metastases of TVT in the left eye and left cerebral hemisphere were found, showing no specific staining for CD3, immunoglobulin (Ig) G, IgM and lambda light chains. It was therefore concluded that the tumour growth was progressive, and that there was an absence of local humoral immune response against TVT in this case.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10812546/