Peer-reviewed veterinary case report
C‐reactive protein concentrations in canine acute pancreatitis
- Journal:
- Journal of Veterinary Emergency and Critical Care
- Year:
- 2004
- Authors:
- Holm, Jennifer L. et al.
- Species:
- dog
Plain-English summary
In a study involving 16 dogs diagnosed with acute pancreatitis (a condition where the pancreas becomes inflamed) and 16 healthy dogs, researchers looked at a substance called C-reactive protein (CRP) in their blood. They found that the dogs with pancreatitis had much higher levels of CRP on the day they were diagnosed compared to the healthy dogs. For seven of the dogs that had blood tests on multiple days, the CRP levels decreased significantly over the five days of monitoring. Out of the 16 dogs with pancreatitis, 14 were able to go home after treatment, while 2 had to be euthanized. Overall, the study showed that CRP levels were elevated in dogs with pancreatitis and tended to improve with treatment.
Abstract
AbstractObjective:To determine if C‐reactive protein (CRP) concentration is elevated in spontaneously occurring canine acute pancreatitis (AP), and to measure changes in CRP during the course of hospitalization.Design:Prospective study.Setting:Tufts University School of Veterinary Medicine Foster Hospital for Small Animals.Animals:Sixteen client‐owned dogs with AP and 16 healthy controls.Interventions:Blood samples were obtained from the AP group on the day of diagnosis (Day 1), and on Days 3 and 5, unless the dog died or was discharged from the hospital. Blood was obtained from the control dogs once.Measurements and main results:Serum CRP was measured using a commercial immunoassay for each dog with AP and for healthy controls. Day 1 CRP concentrations were significantly higher in the AP group (56.1±12.7 μg/mL) compared with controls (2.8±1.3 μg/mL;P<0.001). For the 7 dogs that had samples collected on all 3 days, the mean CRP concentrations decreased significantly (P=0.043) over the 5 days of measurement. Of the 16 dogs with AP, 14 were discharged from the hospital and 2 were euthanized.Conclusions:Serum CRP concentrations were elevated in this group of 16 dogs with spontaneously occurring AP. In the 7 dogs that had measurements on all 3 days, the mean CRP concentration decreased from the day of diagnosis to the measurement made 5 days later.
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Search related cases →Original publication: https://doi.org/10.1111/j.1534-6935.2004.04010.x