Peer-reviewed veterinary case report
Serum concentrations of canine pancreatic lipase immunoreactivity and C-reactive protein for monitoring disease progression in dogs with acute pancreatitis
- Journal:
- Journal of Veterinary Internal Medicine
- Year:
- 2021
- Authors:
- Keany, Kirstin M. et al.
- Affiliation:
- MedVet New Orleans, Louisiana and MedVet Mandeville, Louisiana ,
- Species:
- dog
Plain-English summary
In this study, researchers looked at whether certain blood tests could help track how well dogs with acute pancreatitis (a sudden inflammation of the pancreas) are doing while they are hospitalized. They tested 13 dogs that were diagnosed with this condition and measured levels of canine pancreatic lipase immunoreactivity (cPLI) and C-reactive protein (CRP) in their blood before treatment, daily during their stay, and a week after they went home. The results showed that dogs who recovered had better activity scores compared to those who did not survive, and higher levels of cPLI and CRP were linked to better activity scores. This suggests that cPLI and possibly CRP could be useful for monitoring changes in dogs with acute pancreatitis, but more research with more dogs is needed to confirm these findings.
Abstract
Abstract Background Reliable biomarkers for monitoring disease progression and management in dogs with acute pancreatitis have not been described. Objective To determine if serum concentrations of canine pancreatic lipase immunoreactivity (cPLI) and C-reactive protein (CRP) can be used as biomarkers for disease progression in hospitalized dogs with acute pancreatitis. Animals Thirteen hospitalized dogs with acute pancreatitis diagnosed based on clinical signs, serum cPLI concentrations, and imaging findings were enrolled. Methods Serum cPLI and CRP concentrations were determined before and then daily during hospital management and 1 week after hospital discharge. Modified canine activity index (MCAI) and canine acute pancreatitis clinical severity index (CAPCSI) scores were calculated daily for each patient while hospitalized. Results The MCAI scores (P = .03) but not CAPCSI scores (P = .31) were significantly different between dogs that survived to discharge (n = 11) and those that did not (n = 2). Serum cPLI concentration was positively correlated with MCAI (rho = 0.42; P = .01). Serum CRP concentration also was positively correlated with the MCAI (rho = 0.42, P = .01). Conclusions Serum cPLI and possibly CRP could be used as objective biomarkers for clinical changes in hospitalized dogs with acute pancreatitis. Additional studies involving larger numbers of dogs would be warranted to evaluate the broader impact of these findings.
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Search related cases →Original publication: https://doi.org/10.1111/jvim.16218