Peer-reviewed veterinary case report
C-reactive protein levels in dogs with kidney disease
By Raila, Jens et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2011·University Potsdam, Germany·View original on PubMed →
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Original publication title: C-reactive protein concentrations in serum of dogs with naturally occurring renal disease.
- Species:
- dog
Plain-English summary
A group of dogs with kidney disease had their blood tested for a protein called C-reactive protein (CRP), which can indicate inflammation. The study found that dogs with more severe kidney issues had higher levels of CRP in their blood compared to healthy dogs. Specifically, the sick dogs showed CRP levels that were significantly elevated, suggesting that inflammation plays a role in their kidney problems. This information could help veterinarians assess the severity of kidney disease in dogs and guide treatment options.
People also search for: dog kidney disease symptoms · elevated CRP in dogs · dog kidney function tests
Abstract
The current study was undertaken to investigate the relation between serum C-reactive protein (CRP) concentrations and parameters of renal function in dogs with naturally occurring renal disease. Dogs were assigned to groups according to plasma creatinine concentration, urinary protein-to-creatinine ratio (UP/UC), and exogenous plasma creatinine clearance (P-Cl(Cr)) rates. Group A (healthy control dogs; n = 8): non-azotemic (plasma creatinine <125 µmol/l) and nonproteinuric (UP/UC <0.2), with P-Cl(Cr) rates >90 ml/min/m(2); group B (n = 11): non-azotemic, nonproteinuric dogs with reduced P-Cl(Cr) rates (50-89 ml/min/m(2)); group C (n = 7): azotemic, borderline proteinuric dogs (P-Cl(Cr) rates: 22-67 ml/min/m(2)); and group D (n = 6): uremic, proteinuric dogs (not tested for P-Cl(Cr)). The serum CRP concentrations were measured via commercial enzyme-linked immunosorbent assay. The CRP concentrations in the clinically healthy dogs (group A) ranged from 2.09 mg/l to 8.60 mg/l (median: 3.21 mg/l). In comparison with dogs of group A, median CRP concentrations were significantly (P < 0.01) elevated in dogs of group B (17.6 mg/l, range: 17.0-19.2 mg/l), group C (24.8 mg/l, range: 18.0-32.5 mg/l), and group D (59.7 mg/l, range: 17.7-123 mg/l). Serum CRP was significantly related to P-Cl(Cr) (r = -0.83; P < 0.001), plasma creatinine (r = 0.81; P < 0.001), UP/UC (r = 0.70; P < 0.001), and leukocytes (r = 0.49; P < 0.01). The significant relations between serum CRP concentrations and biochemical parameters of kidney function in plasma and urine suggest that a stimulation of the acute phase response is implicated in the pathogenesis of canine renal disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21908313/