Peer-reviewed veterinary case report
How uterine infections lower key brain signals in female dogs
By Rybska, Marta et al.·Published in Animal reproduction science·2022·Department of Preclinical Sciences and Infectious Diseases·View original on PubMed →
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Original publication title: Canine cystic endometrial hyperplasia and pyometra may downregulate neuropeptide phoenixin and GPR173 receptor expression.
- Species:
- dog
Plain-English summary
A female dog with a uterine infection called pyometra may have lower levels of a neuropeptide called phoenixin, which could affect her reproductive health. In a study, researchers found that dogs with pyometra or another condition called cystic endometrial hyperplasia had significantly reduced levels of phoenixin and its receptor compared to healthy dogs. This suggests that these uterine diseases might disrupt normal hormonal and inflammatory responses in female dogs. Understanding these changes could help veterinarians better diagnose and treat uterine disorders in dogs.
People also search for: dog pyometra symptoms · female dog reproductive health · cystic endometrial hyperplasia treatment
Abstract
The most common uterine diseases affecting bitches are cystic endometrial hyperplasia (CEH) and pyometra. The neuropeptide phoenixin (PNX) and its receptor (GPR173) are potential key factors involved in the proliferative and inflammatory regulation of the reproductive system in females. This study aimed to evaluate the expression of PNX and GPR173 by qPCR, western blot and immunofluorescence assays in the endometrium of bitches suffering from CEH or pyometra compared to clinically healthy females. Additionally, PNX and progesterone (P4) plasma concentrations were analysed. The results showed a significantly lower expression levels of PNX and GPR173 (mRNA and protein production) in bitches with the CEH or pyometra groups compared to healthy animals. Immunofluorescence staining examination also confirmed a lower concentration of PNX and GPR173 signals in bitches with pathological uteri. Moreover, a lower concentration of PNX blood levels in bitches suffering from pyometra was observed. The PNX concentration was negatively correlated with P4 but only in healthy bitches. These results illustrate that the development of canine uterine disorders may cause a lower expression of PNX and its receptor GPR173.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35121414/