Peer-reviewed veterinary case report
Rare skin lupus in two mixed breed sibling dogs and treatment response
By Dumitrache, Mirabela Oana et al.·Published in Veterinary dermatology·2025·Department of Parasitology and Parasitic Diseases·View original on PubMed →
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Original publication title: Canine exfoliative cutaneous lupus erythematosus in two mixed breed littermates.
- Species:
- dog
Plain-English summary
Two mixed-breed puppies were diagnosed with a rare skin condition called exfoliative cutaneous lupus erythematosus (ECLE), which caused severe skin issues. Their veterinarian confirmed the genetic mutation associated with this condition and treated them with a medication called oclacitinib. Fortunately, both puppies showed a positive response to the treatment, helping to improve their skin health and overall comfort.
People also search for: dog skin problems lupus · oclacitinib for dogs · puppy skin condition treatment
Abstract
Canine exfoliative cutaneous lupus erythematosus (ECLE) is the rarest variant of cutaneous lupus in dogs and has strong breed predilections. This report presents the clinical, histopathological and immunohistochemical features of two ECLE cases in mixed breed littermates and confirms the expected genetic mutation. A therapeutic response to oclacitinib also is documented.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39344864/