Peer-reviewed veterinary case report
Protein in urine and treatment options for dog kidney inflammation
By Grauer, G F·Published in The Journal of small animal practice·2005·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Canine glomerulonephritis: new thoughts on proteinuria and treatment.
- Species:
- dog
Plain-English summary
A dog with kidney disease may show signs like increased thirst, frequent urination, or weight loss due to a condition called glomerulonephritis, which involves damage to the kidney's filtering units. This damage leads to protein leaking into the urine, a symptom known as proteinuria. Treatment often focuses on finding and addressing any underlying causes, such as inflammation or immune issues. In cases where the cause isn't clear, medications like angiotensin-converting enzyme inhibitors can help reduce protein levels in the urine and may slow down the progression of the disease.
People also search for: dog kidney disease symptoms · glomerulonephritis treatment in dogs · protein in dog urine causes
Abstract
Glomerular disease in the dog is not only a common form of renal disease but also an important cause of chronic renal failure. The presence of immune complexes in glomerular capillary walls is a major cause of canine glomerular disease and is commonly referred to as glomerulonephritis. Leakage of plasma proteins, principally albumin, across the damaged glomerular capillary walls results in persistent proteinuria--the clinicopathological hallmark of glomerulonephritis. Recent evidence suggests that, in addition to being a marker of disease, persistent proteinuria is associated with progressive glomerular and tubulointerstitial lesions and loss of additional nephrons. Perhaps the best treatment for glomerulonephritis is the identification and correction of any underlying inflammatory, immune-mediated or neoplastic disease that results in the deposition or formation of glomerular immune complexes. In cases of idiopathic glomerulonephritis, angiotensin-converting enzyme inhibitors have been shown to decrease proteinuria and potentially slow disease progression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16245660/