Peer-reviewed veterinary case report
Dog with brain tumor showing rosette-like collagen deposits
By Saito, Ryo et al.·Published in The Journal of veterinary medical science·2022·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: Canine intracranial meningioma with rosette-like collagen deposits.
- Species:
- dog
Plain-English summary
A 13-year-old female Miniature Dachshund was brought in for seizures, and an intracranial mass was found in her brain. After surgery to remove the mass, it returned three months later. The mass was identified as a type of tumor called meningioma, which had unusual collagen deposits that were observed under a microscope. Unfortunately, the tumor's recurrence indicates that further treatment may be needed, and the dog's condition will need to be monitored closely by her veterinarian.
People also search for: dog seizures treatment · Miniature Dachshund brain tumor · meningioma in dogs · dog surgery for brain mass
Abstract
A 13-year-old female Miniature Dachshund showed seizures and an intracranial mass was seen in the left temporal lobe. Three months after first surgical resection, a recurrence lesion was recognized. Histopathologically, proliferation of spindle cells with diffuse rosette-like eosinophilic deposits, which stained blue with Masson's trichrome stain, was observed. In electron microscopy, the rosette-like deposits were consisted of bundles of minute filaments which were assumed to be collagenous fibrils. Immunohistochemically, the neoplastic cells were positive for vimentin and cytokeratin, and negative for E-cadherin, S100, glial fibrillary acidic protein (GFAP), oligodendrocyte transcription factor (Olig2), and CD204. The rosette-like collagen deposits were positive for type 4 collagen and negative for type 1 collagen. In this report, we describe histopathological features of a canine meningioma with the rosette-like collagen deposits.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35491093/