Peer-reviewed veterinary case report
Seizure risk factors in dogs with brain tumors
By Schwartz, M et al.·Published in The Journal of small animal practice·2011·Department of Veterinary Clinical Sciences·View original on PubMed →
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Original publication title: Canine intracranial neoplasia: clinical risk factors for development of epileptic seizures.
- Species:
- dog
Plain-English summary
A group of dogs with brain tumors was studied to see if they had seizures and what factors might increase that risk. Out of 68 dogs with confirmed brain tumors, 42 experienced seizures, while 26 did not. The types of tumors included meningiomas and gliomas, among others. The study found that dogs with tumors in the frontal lobe, those showing significant enhancement on MRI scans, or those with certain brain herniations were more likely to have seizures. Understanding these risk factors can help veterinarians monitor and manage dogs with brain tumors more effectively.
People also search for: dog seizures brain tumor · canine intracranial neoplasia symptoms · dog MRI brain tumor treatment
Abstract
OBJECTIVES: To identify clinical risk factors for seizures in dogs with intracranial neoplasia. METHODS: A cross-sectional retrospective study of 68 dogs with histopathologically confirmed primary or secondary intracranial neoplasia, complete clinical history and magnetic resonance imaging of the brain was conducted. Signalment and clinical history were retrieved from clinical records and magnetic resonance images of the brain were re-evaluated. Prevalence of findings was compared between dogs with and without seizures. RESULTS: Forty-two dogs had tumour-related seizures, the remaining 26 were seizure-free. Tumour types included meningioma (23 dogs with and 5 without seizures), glioma (9 dogs with and 6 without seizures), choroid plexus tumour (2 dogs without seizures), neuroblastoma (1 dog with seizures) and metastatic/invasive tumours including lymphoma (9 dogs with and 13 without seizures). On the basis of multi-variable logistic regression analysis, risk factors for seizures associated with intracranial neoplasia were magnetic resonance imaging findings consistent with the presence of neoplastic tissue in frontal lobe [odds ratio (OR) 9·61; 95% confidence interval (CI) 2·59 to 35·61], marked gadolinium enhancement (OR 10·41; 95% CI 2·07 to 52·30) and magnetic resonance imaging findings of subfalcine and/or subtentorial herniation (OR 3·88; 95% CI 1·10 to 13·71). CLINICAL SIGNIFICANCE: Dogs with primary or secondary intracranial neoplasia are at risk of seizures, particularly those with tumours that affect the frontal lobe, enhance markedly with gadolinium, or cause subfalcine and/or subtentorial herniation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21954970/