Peer-reviewed veterinary case report
Inverted papillomas in dogs linked to four papillomaviruses
By Lange, Christian E et al.·Published in Veterinary dermatology·2010·Clinic for Small Animal Internal Medicine·View original on PubMed →
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Original publication title: Canine inverted papillomas associated with DNA of four different papillomaviruses.
- Species:
- dog
Plain-English summary
A 5-year-old beagle was diagnosed with unusual skin growths called inverted papillomas, which are dome-shaped nodules on the skin. These lesions can be caused by different types of papillomaviruses, and tests showed that this dog had a virus linked to the growths. The study found that four dogs had inverted papillomas, each associated with different papillomavirus DNA. This suggests that multiple types of viruses can lead to these skin issues in dogs. Treatment options may vary based on the specific virus involved, so it's important to consult with a veterinarian for the best approach.
People also search for: dog skin growths papillomavirus · beagle skin problems · inverted papillomas in dogs treatment
Abstract
Inverted papillomas are uncommon papillomavirus (PV)-induced canine skin lesions. They consist of cup- to dome-shaped dermal nodules with a central pore filled with keratin. Histologically they are characterized by endophytic projections of the epidermis extending into dermis. Cytopathic effects of PVs infection include the presence of clumped keratohyalin granules, koilocytes and intranuclear inclusion bodies. Different DNA hybridization studies carried out with a canine oral papillomavirus (COPV) probe suggested that a different PV than COPV might cause these lesions. Canine papillomavirus 2 (CPV2) was discovered a few years ago in inverted papillomas of immunosuppressed beagles. Two other cases, presenting with distinct clinical and histological features have also been described. This study was carried out on four dogs with clinical and histological signs of inverted papillomas. Molecular biological analyses confirmed that PV DNA was present in all four lesions but demonstrated that the sequences in each case were different. One corresponded to COPV, the second to CPV2, and the third and fourth to unknown PVs. These findings suggest that inverted papillomas are not caused by one single PV type. Similar observations have also been made in human medicine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20042038/