Peer-reviewed veterinary case report
Neurological signs in dogs with large T-cell intravascular lymphoma
By Saulo Romero Felix Gonçalves et al.·Published in Brazilian Journal of Veterinary Pathology·2025·Laboratory of Histopathology, Department Veterinary Medicine, Federal Rural University of the Pernambuco, Recife, PE, Brazil, BR·View original on DOAJ →
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Original publication title: Canine large t-cell intravascular lymphoma – report of two cases
- Species:
- dog
Plain-English summary
A 7-year-old mixed breed dog and a 9-year-old Labrador were brought in with neurological symptoms, including difficulty walking, seizures, and unsteady movements. Both dogs were diagnosed with a rare type of cancer called large T-cell intravascular lymphoma, which affects the blood vessels and can impact the brain. Unfortunately, this condition is quite complex, and treatment options are limited. The dogs received supportive care, but the prognosis for recovery is generally poor due to the aggressive nature of this cancer.
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Abstract
Intravascular lymphoma is rare in all species and is characterized by the intravascular proliferation of neoplastic lymphocytes, with the central nervous system being the most affected site. The aim was to report two cases of dogs diagnosed with large T-cell intravascular lymphoma. Both dogs showed neurological signs, including ataxia, seizures, and difficulty walking. Macroscopically, malacia in the brain were noted. Microscopically, there was a predominance of large neoplastic lymphocytes within the vasculature, with CD3 positive and negative to CD20, CD79a, PAX-5 immunohistochemical staining, confirming large T-cell intravascular lymphoma. The complexity of this neoplasm highlights the importance of interdisciplinary collaboration among veterinarians for differential diagnosis of central nervous system diseases.
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Search related cases →Original publication on DOAJ: https://doi.org/10.24070/bjvp.1983-0246.018012