Peer-reviewed veterinary case report
Does leishmaniasis treatment stop parasite spread from dogs' skin
By João, A et al.·Published in Journal of veterinary medicine. A, Physiology, pathology, clinical medicine·2006·Unidade de Leishmanioses e Centro de Malá·View original on PubMed →
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Original publication title: Canine leishmaniasis chemotherapy: dog's clinical condition and risk of Leishmania transmission.
- Species:
- dog
Plain-English summary
A group of dogs with leishmaniasis, a disease caused by a parasite, were treated to see if their condition improved and if they could still spread the parasite. Some dogs showed parasites in their bone marrow, but those treated with medications like meglumine antimoniate or allopurinol had better outcomes, with no parasites found in their skin. However, the treatments didn't completely eliminate the parasite, and relapses could happen if treatment stopped. Overall, the medications helped improve the dogs' health and reduced the risk of spreading the disease.
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Abstract
The aim of this study was to investigate whether treatment against canine leishmaniasis reduced the presence of Leishmania in the healthy skin of dogs, affecting the capacity of parasite transmission. A total of 37 dogs from an endemic region of leishmaniasis were studied. Thirteen symptomatic animals revealed parasites in the bone marrow and eight had also in the skin. Five of the 22 dogs that had been treated with meglumine antimoniate alone, meglumine antimoniate or trifluralin followed by allopurinol or just with allopurinol had the parasite in bone marrow but none showed Leishmania in the skin. One dog that was treated only with aminosidine was polisymptomatic and had parasites in bone marrow and skin. The different treatments used in this study did not completely eliminate the parasite allowing relapses to occur when the treatment is discontinued, but the use of meglumine antimoniate or allopurinol, alone or combined may improve dogs clinical condition and reduce or eliminate the parasite from the skin decreasing the probability of Leishmania transmission.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17105576/