Peer-reviewed veterinary case report
What We Know About Aggressive Large B-Cell Lymphoma in Dogs
By Aresu, Luca·Published in Frontiers in veterinary science·2016·Department of Comparative Biomedicine and Food Science, Italy·View original on PubMed →
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Original publication title: Canine Lymphoma, More Than a Morphological Diagnosis: What We Have Learned about Diffuse Large B-Cell Lymphoma.
- Species:
- dog
Plain-English summary
A dog with diffuse large B-cell lymphoma (DLBCL), a common and aggressive type of cancer, may show symptoms like swollen lymph nodes, weight loss, or lethargy. This type of lymphoma can progress quickly, making it challenging to predict how well a dog will respond to treatment. Recent research has focused on understanding the different subtypes of DLBCL to improve treatment options. While there are still many questions, ongoing studies aim to find better ways to manage this serious condition and enhance the effectiveness of therapies.
People also search for: dog lymphoma symptoms · diffuse large B-cell lymphoma treatment · canine cancer prognosis
Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common canine aggressive B-cell lymphoma worldwide, and new recent molecular approaches have shown that DLBCL constitutes a heterogeneous tumor that cannot be unraveled by morphology and immunophenotype. DLBCL behaves aggressively, typically progressing over a short period of time, and the therapy response may be difficult to be predicted. Recently, the rate of bone marrow infiltration by flow cytometry has been demonstrated to be prognostic, but more sensible markers are needed. As the clinical behavior is different, there is vast clinical and basic research devoted to identifying prognostically or biologically distinct DLBCL subgroups. Transcriptomic analysis by gene expression profile, copy number variations by array comparative genomic hybridization and epigenetic perturbations have tentatively described this heterogeneity. Molecular subgroups using oncogenic pathways and target genes have also been correlated to different outcome in a small number of cases. The objectives of this review are to summarize the current knowledge on the biology, clinical, and pathological characteristics of canine DLBCL. To date, DLBCL probably is the most investigated tumor in veterinary medicine, and its relevance as spontaneous model for human DLBCL has been confirmed by these studies. In future, these discoveries will ultimately lead to a better understanding of the underlying disease mechanisms, possibly translating into more effective therapeutic strategies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27630997/