Peer-reviewed veterinary case report
Response to two chemotherapy treatments for dog lymphoma
By Dobson, J. M. & Gorman, N. T.·Published in Journal of Small Animal Practice·1994·View original on Crossref →
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Original publication title: Canine multicentric lymphoma 2: Comparison of response to two chemothera‐peutic protocols
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with multicentric lymphoma (a type of cancer) were treated with a combination of chemotherapy drugs, including cyclophosphamide, vincristine, and prednisolone. Some dogs received an additional drug called cytosine arabinoside for the first four days. After six weeks, 88% of the dogs showed improvement, either completely or partially, and the average survival time was about 37 weeks. However, dogs in more advanced stages of the disease had a poorer outlook, and those who had received corticosteroids before treatment did not respond as well.
People also search for: dog lymphoma treatment · canine cancer survival rates · chemotherapy for dogs with lymphoma
Abstract
ABSTRACTThis paper describes the chemotherapeutic response of 90 cases of canine multicentric lymphoma. All the dogs were treated with a combination protocol using cyclophosphamide, vincristine and prednisolone. Forty‐seven dogs received additional intravenous cytosine arabinoside on the first four days of treatment. Eighty‐eight per cent of all cases had shown either a complete or partial response to this treatment at six weeks from the start of treatment and the overall mean survival time was 37 weeks (SD = 35.8). There was no significant difference in response or survival rates between the two treatment groups. The age and sex of the patient, the clinical stage of the disease and previous treatment with corticosteroids were all analysed to determine whether these parameters were of prognostic significance. Those dogs in clinical stages 4 and 5 carried a worse prognosis than those in stages 1 to 3. Previous treatment with corticosteroids adversely affected both tumour response and patient survival rates.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1748-5827.1994.tb03574.x