Peer-reviewed veterinary case report
French Bulldog with rare skin T-cell lymphoma and skin lumps
By Kondo, Hitoshi et al.·Published in Veterinary medicine and science·2019·Kondo Animal Hospital, Japan·View original on PubMed →
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Original publication title: Canine non-epitheliotropic CD4-positive cutaneous T-cell lymphoma: a case report.
- Species:
- dog
Plain-English summary
A 5-year-old spayed female French Bulldog was brought in with multiple bumps on her skin, particularly around her shoulder area. After a skin biopsy, the vet found that these bumps were caused by a type of cancer called cutaneous T-cell lymphoma, which affects the skin. The vet surgically removed the affected areas, and the dog recovered well without any signs of the cancer returning for about a year. Unfortunately, she later passed away in a traffic accident unrelated to her skin condition.
People also search for: French Bulldog skin bumps · dog cutaneous T-cell lymphoma treatment · skin cancer in dogs
Abstract
A 5-year-old, spayed female French Bulldog presented with multiple papules on the skin of the scapular area. Histopathological examination of punch biopsy samples revealed dense infiltration of small lymphoid cells in the superficial dermis and in areas surrounding hair follicles. Immunohistochemical analysis indicated that these cells were positive for CD3, CD4, and TCRαβ, but negative for CD1c, CD8α, CD8β, CD11c, CD20, CD45RA, CD90, MHC-II, and TCRγδ. In addition, CD45 was highly expressed, and the proliferation fraction was very low. Molecular clonality of T-cell receptor G chains yielded a clonal result. The skin lesions were surgically excised because they had progressed to the lateral front leg. Postoperative clinical course was favorable, and recurrence was not observed until the dog died in a traffic accident, approximately 1 year later.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30548472/