Peer-reviewed veterinary case report
English Setter puppies with skin rash from parvovirus infection
By Woldemeskel, Moges et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2011·The University of Georgia, United States·View original on PubMed →
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Original publication title: Canine parvovirus-2b-associated erythema multiforme in a litter of English Setter dogs.
- Species:
- dog
Plain-English summary
A litter of English Setter puppies developed skin lesions at just 2 weeks old, which were diagnosed as erythema multiforme (EM), a condition that causes red patches on the skin. Testing revealed that the puppies were infected with Canine parvovirus-2 (CPV-2), a virus known for causing severe gastrointestinal issues in dogs. The presence of the virus was confirmed in various tissues, including the skin and intestines. While the puppies had serious symptoms, the report highlights the need for veterinarians to consider CPV as a potential cause of skin problems like EM in dogs.
People also search for: English Setter puppy skin lesions · parvovirus treatment in puppies · erythema multiforme in dogs
Abstract
Erythema multiforme (EM) was diagnosed in a litter of English Setter puppies. The puppies developed erythematous cutaneous lesions at the age of 2 weeks. Microscopically, there was individual keratinocyte apoptosis associated with lymphocyte exocytosis in all layers of the epidermis. Intranuclear viral inclusions were seen in multiple tissues and organs. Tissues from the tongue, lymph node, spleen, skin, and small intestine were positive for Canine parvovirus-2 (CPV-2) and negative for Canine distemper virus (CDV) and Canid herpesvirus 1 by fluorescent antibody test. Negative-staining electron microscopy detected parvovirus particles in the intestinal contents. The skin and small intestine were positive for CPV-2b and negative for CDV by polymerase chain reaction. The mucocutaneous junctions and small intestines stained positive for CPV by immunohistochemistry. The present report documents CPV-2b-associated EM in a litter of English Setters and substantiates the single previous report associating EM with CPV-2. The finding suggests that CPV should be considered as a possible cause of EM in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21908294/