Peer-reviewed veterinary case report
Kidney damage in dogs after eating grapes or raisins
By Morrow, Carla M K et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2005·University of Illinois at Urbana-Champaign, United States·View original on PubMed →
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Original publication title: Canine renal pathology associated with grape or raisin ingestion: 10 cases.
- Species:
- dog
Plain-English summary
Ten dogs developed serious kidney problems after eating grapes or raisins, with symptoms appearing after they consumed a significant amount. All dogs showed damage to the kidney's filtering units, but some were able to start healing. The dogs were treated for acute kidney failure, and with prompt care, there was a chance for recovery. This highlights the dangers of grapes and raisins for dogs and the importance of quick veterinary attention if ingestion occurs.
People also search for: dog kidney failure after grapes · symptoms of dog eating raisins · treatment for dog kidney damage
Abstract
Ten dogs suffered acute renal failure after ingesting > or = 3 g/kg (dry matter) of grapes or raisins. All dogs had degeneration or necrosis (or both) of proximal renal tubules with basement membranes remaining intact, and epithelial regeneration was observed in 5 out of 10 cases. Mineralized tubular debris or granular to proteinaceous casts (or both) were present in all cases. A golden-brown, globular, intracellular pigment of varying amounts and sizes was observed in 6 out of 10 cases with variable reaction with Prussian blue. Multifocal fibrinous arteritis of the large colon was seen in 2 out of 5 cases with globulin insudation of vessel wall demonstrated by immunohistochemical staining for immunoglobulin (Ig)G and IgM. Mineral analysis on frozen renal tissue from 2 out of 2 cases revealed mildly elevated Ca:P ratio in both. Clinically significant observations were preservation of the integrity of basement membranes after grape-induced tubular injury and presence of early epithelial regeneration. Thus, recovery may be possible if anuria is aggressively managed. With respect to potential pathophysiologic mechanisms, further research into the roles of calcium homeostasis, vascular reactivity, and the significance of the golden-brown pigment is indicated.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15945377/