Peer-reviewed veterinary case report
Small clear cell T-zone lymphoma in dogs and their outcomes
By Martini, V et al.·Published in Veterinary and comparative oncology·2016·Department of Veterinary Sciences and Public Health, Italy·View original on PubMed →
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Original publication title: Canine small clear cell/T-zone lymphoma: clinical presentation and outcome in a retrospective case series.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with a rare type of lymphoma called small clear cell/T-zone lymphoma were observed to understand their symptoms and outcomes. Most of these dogs were in advanced stages of the disease but showed few noticeable signs, and their blood tests often revealed more issues than their bone marrow. While many dogs had a favorable prognosis and survived longer than expected, some unfortunately passed away quickly, and a few developed other cancers later on. More research is needed to identify which dogs might be at higher risk for complications.
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Abstract
Published studies, taken together, suggest the existence of a single canine lymphoma entity, with a small clear cell appearance by cytological evaluation, a histopathological T-zone pattern and an aberrant CD45-negative T-cell phenotype, mostly characterized by long-term survival. We describe clinical presentation and outcome in a retrospective case series of canine small clear cell/T-zone lymphoma. Despite the reported predisposition of Golden retriever, this breed was not represented in our case series. Most dogs presented with stage V disease, whereas only few had clinical signs or peripheral cytopenias. Blood was almost always more infiltrated than bone marrow. Median survival confirmed the favourable prognosis described in literature, but a few dogs died within a short time. Also, a subgroup of dogs developed second malignancies, eventually leading to death. We did not investigate possible prognostic factors because of the wide variety in treatments, and further studies are needed to identify high-risk animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26040658/