Peer-reviewed veterinary case report
Survival and treatment outcomes in dogs with synovial sarcoma tumors
By Fox, Derek B et al.·Published in Journal of the American Animal Hospital Association·2002·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Canine synovial sarcoma: a retrospective assessment of described prognostic criteria in 16 cases (1994-1999).
- Species:
- dog
Plain-English summary
Sixteen dogs with synovial sarcoma, a type of cancer affecting the joints, were studied to understand how different factors might affect their survival. The researchers found that the stage of the cancer and its histopathological grade did not significantly influence how long the dogs lived. However, dogs that underwent surgery to remove the tumor or had an amputation lived longer than those who did not receive any treatment. This suggests that aggressive treatment may be more important for improving survival than the cancer's stage or grade.
People also search for: dog synovial sarcoma treatment · dog cancer survival rates · canine tumor surgery outcomes
Abstract
Pertinent patient data and biopsied tissue from 16 cases of canine synovial sarcoma (SS) were reviewed. Histopathological grade, clinical stage, and tissue immunoreactivity to cytokeratin (broad stain, AE1/AE3 and cytokeratin 7) and vimentin were determined and correlated with survival. Effect of treatment on survival was similarly evaluated. Neither clinical stage nor histopathological grade significantly affected survival patterns. Tissues from all cases stained >30% positively with vimentin, whereas no tissue from any case exhibited cytokeratin immunoreactivity. Dogs receiving surgical tumor excision or amputation had a significantly higher survivability than those receiving no treatment (P<0.02). Treatment aggressiveness may be more appropriate than clinical staging or tumor grading in predicting survival. Reliability of diagnosing and prognosticating canine SS with current immunohistochemistry protocols should be questioned.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12118688/