Peer-reviewed veterinary case report
Canine T-zone lymphoma diagnosis and outcomes with CD45 loss
By Seelig, D M et al.·Published in Journal of veterinary internal medicine·2014·University of Minnesota·View original on PubMed →
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Original publication title: Canine T-zone lymphoma: unique immunophenotypic features, outcome, and population characteristics.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with T-zone lymphoma, a type of T-cell lymphoma, were studied to understand their unique characteristics and outcomes. This condition is often seen in older dogs, particularly Golden Retrievers, and is marked by swollen lymph nodes and increased white blood cells. The study found that dogs with this lymphoma had a median survival of about 637 days after diagnosis. The researchers identified specific features that can help veterinarians diagnose this type of lymphoma more accurately.
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Abstract
BACKGROUND: Canine T-cell lymphoma (TCL) is clinically and histologically heterogeneous with some forms, such as T-zone lymphoma (TZL), having an indolent course. Immunophenotyping is an important tool in the classification of TCL in people, and can be equally useful in dogs. HYPOTHESIS/OBJECTIVES: We hypothesized that loss of expression of the CD45 antigen is a specific diagnostic feature of TZL. ANIMALS: Twenty dogs with concurrent histology and immunophenotyping by flow cytometry were studied in depth. An additional 494 dogs diagnosed by immunophenotyping were used to characterize the population of dogs with this disease. METHODS: Lymph node biopsies from 35 dogs with TCL were classified by 2 pathologists using WHO criteria. Twenty lymph nodes were from dogs with CD45- TCL and 15 were from CD45+ TCL. The pathologists were blinded to the flow cytometry findings. Outcome information was sought for the 20 dogs with CD45- lymphoma, and population characteristics of the additional 494 dogs were described. RESULTS: All 20 CD45- cases were classified as TZL. The 15 CD45+ cases were classified as aggressive TCL and are described in an accompanying paper. TZL cases had a median survival of 637 days. Examination of 494 additional dogs diagnosed with TZL by immunophenotyping demonstrated that 40% of cases are in Golden Retrievers, are diagnosed at a median age of 10 years, and the majority have lymphadenopathy and lymphocytosis. CONCLUSIONS: TZL has unique immunophenotypic features that can be used for diagnosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24655022/