Canine vascular neoplasia--histologic classification and inmunohistochemical analysis of 221 tumours and tumour-like lesions.

Abstract

A light microscopic evaluation of 221 canine vascular tumours and tumour-like lesions, supplemented by immunohistochemistry (von Willebrand Factor, CD31, vimentin), revealed a high degree of conformity with similar conditions in humans. Four main categories of tumours are reported, i.e. benign types: haemangiomas (n=127) and lymphangioma (n=1); tumour-like lesions: papillary endothelial hyperplasia (n=8) and vascular ectasias (n=2); neoplasms of intermediate malignancy: haemangioendotheliomas (n=27), and the obvious malignant form: angiosarcomas (n=57). Further classification showed that all subtypes had their human counterparts. Papillary endothelial hyperplasia and arteriovenous and venous haemangiomas are described for the first time in dogs. The combination of conventional histopathologic methods and immunohistochemistry was in many cases very useful diagnostically, the latter technique being in some cases indispensable for establishing a definite diagnosis. In general CD31 was the most useful marker for tumours originating from endothelial cells, especially for poorly differentiated haemangiosarcomas.