Peer-reviewed veterinary case report
VEGF protein levels linked to growth in dog mammary tumors
By Santos, A A F et al.·Published in Journal of comparative pathology·2010·Instituto de Ciê·View original on PubMed →
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Original publication title: Immunohistochemical expression of vascular endothelial growth factor in canine mammary tumours.
- Species:
- dog
Plain-English summary
A study looked at 48 benign and 64 malignant mammary tumors in dogs to understand the role of a protein called vascular endothelial growth factor (VEGF) in their growth. The researchers found that VEGF was present in both types of tumors, but its levels did not seem to relate to how aggressive the tumors were or their ability to spread. This means that while VEGF is involved in tumor development, it doesn't help predict how a tumor will behave. The findings suggest that other factors might be more important in determining the prognosis for dogs with mammary tumors.
People also search for: dog mammary tumor treatment · canine breast cancer prognosis · what is VEGF in dog tumors
Abstract
The histopathological and clinical aspects of canine mammary tumours (CMTs) have been widely studied, but the variation in the biological behaviour of these neoplasms hampers the identification of prognostic factors. Sustained angiogenesis has been suggested to be one of the most important factors underlying tumour growth and invasion. This process involves the action of several growth factors including vascular endothelial growth factor (VEGF). The present study characterizes the relationship between immunohistochemical expression of VEGF and gross (e.g. size and tissue fixation) and microscopical (e.g. type, growth, necrosis, lymphoid infiltration, lymph node metastasis, histological grade and proliferation index) features of CMTs. Forty-eight benign and 64 malignant CMTs were evaluated. Statistical analysis failed to show a significant relationship between VEGF expression and the pathological features, suggesting that VEGF expression occurs in both benign and malignant tumours and is independent of histological type, proliferation, tissue invasion or local metastatic capacity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20570280/