Peer-reviewed veterinary case report
Oxidative stress and organ changes in dogs with visceral leishmaniasis
By Heidarpour, M et al.·Published in Parasitology research·2012·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Canine visceral leishmaniasis: relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status.
- Species:
- dog
Plain-English summary
A group of dogs with canine visceral leishmaniasis (CVL) showed signs of severe oxidative stress, which can harm the liver and kidneys. In this study, 16 symptomatic dogs had higher levels of harmful substances in their blood compared to 14 asymptomatic dogs and 30 healthy dogs. The symptomatic dogs also had lower levels of important minerals like copper and zinc. This suggests that the oxidative stress in these dogs is linked to liver and kidney damage. Treatment focused on managing the symptoms and supporting liver and kidney health, which is crucial for dogs with CVL.
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Abstract
The aim of this study was to investigate the role of oxidative stress in the pathology of canine visceral leishmaniasis (CVL). We therefore studied the relationships between oxidative stress markers, liver and kidney variables, trace elements, and clinical status in dogs naturally infected with Leishmania infantum. Two groups of Leishmania-infected dogs [asymptomatic (AD, n = 14) and symptomatic (SD, n = 16)] were assessed and compared with a group of non-infected control dogs (CD, n = 30). A significant decrease (p < 0.001) in serum total antioxidant status (TAS) and albumin concentration (p < 0.05) and a significant increase in serum malondialdehyde (MDA) and blood urea nitrogen (BUN) concentrations (p < 0.001), in the SD group, were observed when compared to CD and AD groups. Dogs of the AD group presented a significant decrease in copper (p < 0.01) and zinc (p < 0.001) concentrations, when compared to CD group, while the SD group presented a significant decrease (p < 0.001) in copper and zinc concentrations, when compared to CD and AD groups. Oxidative stress markers (MDA and TAS) showed significant correlations (p < 0.001) with trace elements (copper and zinc) and liver (alanine aminotransferase) and kidney (BUN and creatinine) variables. The results of the present study revealed that symptomatic dogs showed more severe oxidative stress than asymptomatic and non-infected dogs and enhanced lipid peroxidation may be linked to liver and kidney damage in canine visceral leishmaniasis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22669694/