Peer-reviewed veterinary case report
Dog with kidney stones and Corynebacterium urealyticum urinary
By Fleischhacker, Sn et al.·Published in Australian veterinary journal·2014·Clinic of Small Animal Medicine, Germany·View original on PubMed →
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Original publication title: Carbonate apatite nephrolithiasis associated with Corynebacterium urealyticum urinary tract infection in a dog.
- Species:
- dog
Plain-English summary
An 11-month-old female spayed mixed-breed dog was brought to the vet due to a urinary tract infection caused by a tough-to-treat bacteria called Corynebacterium urealyticum. The dog also had kidney stones made of carbonate apatite, which were confirmed through imaging tests. Standard antibiotics didn't work, but the vet found that the bacteria were sensitive to a specific antibiotic called linezolid. After treating the dog with linezolid and switching to a urine-acidifying diet, the infection cleared up, and the kidney stones were resolved.
People also search for: dog urinary tract infection treatment · dog kidney stones diet · Corynebacterium urealyticum in dogs
Abstract
BACKGROUND: Urinary tract infections caused by Corynebacterium urealyticum are uncommon in veterinary medicine. Encrusted cystitis, encrusted pyelitis and uroliths have been described as complications in humans, but only encrusted cystitis and cystoliths have been reported in dogs so far. Because C. urealyticum is usually resistant to all standard antibacterial drugs, antimicrobial treatment and elimination of this microorganism are challenging. CASE REPORT: An 11-month-old female spayed mixed-breed dog was evaluated because of a C. urealyticum urinary tract infection, mineralisation within both renal pelvises and failure of antimicrobial treatment. Physical examination, haematology and biochemistry were unremarkable. Radiographic and ultrasonographic examinations confirmed bilateral nephrolithiasis. Voided uroliths were composed of 100% carbonate apatite. Urinalysis was indicative of bacterial infection. Aerobic culture of the urine and 16S rRNA sequencing identified significant growth of C. urealyticum and susceptibility testing revealed sensitivity to only vancomycin and linezolid. CONCLUSION: Treatment with the oxazolidinone antibacterial, linezolid, in combination with a urine-acidifying diet resulted in elimination of this multiresistant microorganism and complete resolution of nephrolithiasis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24766046/