Peer-reviewed veterinary case report
Dog with nerve tumor invading skull and brain bone loss
By Kyosuke Hidari et al.·Published in Frontiers in Veterinary Science·2022·Neuro Vets Animal Neurology Clinic, Kyoto, Japan, CH·View original on DOAJ →
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Original publication title: Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog
- Species:
- dog
Plain-English summary
A 13-year-old male Toy Poodle was brought to the vet because he suddenly had trouble with balance and coordination, a condition known as vestibular disorder. Imaging tests showed a large mass in his skull that was damaging the bone. The mass was identified as a malignant peripheral nerve sheath tumor, which is a type of cancer that affects the nerves. Unfortunately, due to the aggressive nature of the tumor, treatment options may be limited, and the prognosis can be poor.
People also search for: dog vestibular disease treatment · Toy Poodle tumor symptoms · malignant nerve sheath tumor in dogs
Abstract
A 13-year-old castrated male Toy Poodle presented with an acute vestibular disorder. Magnetic resonance imaging and computed tomography revealed a large oval space-occupying mass with skull destruction located from the subcutaneous tissue to the posterior fossa region. Histopathologically, the mass was a bundled growth of spindle-shaped mesenchymal tumor cells between the myofibrillar and collagen bundles. The cells were moderately irregular in size and had eosinophilic stained cytoplasm. The cells were highly atypical and had rare mitotic figures. Neoplastic cells were immunoreactive for S100, GFAP, Olig-2, SOX10 and immunonegative for NF, E-cadherin, and Claudin-1. Collective findings were presumptive with a diagnosis of malignant peripheral nerve sheath tumor.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2022.977099