Peer-reviewed veterinary case report
Cat with rare primary intestinal histiocytic sarcoma and treatment
By Pérez, Andrea et al.·Published in Frontiers in veterinary science·2025·AniCura Ars Veterinaria Hospital Veterinari, Spain·View original on PubMed →
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Original publication title: Case Report: Primary intestinal histiocytic sarcoma in a cat.
- Species:
- cat
Plain-English summary
An 11-year-old male cat was brought to the vet with sudden stomach issues, which turned out to be caused by a rare and aggressive tumor called primary intestinal histiocytic sarcoma. After several tests, including ultrasound and tissue analysis, the vet confirmed the diagnosis. The cat had surgery to remove the tumor and then received chemotherapy, which helped him fully recover. Two years later, he is still healthy and free of the disease. This case shows how important it is to use various diagnostic tools when dealing with intestinal problems in cats.
People also search for: cat stomach issues · cat intestinal tumor treatment · chemotherapy for cat cancer · signs of cancer in cats
Abstract
Histiocytic sarcoma (HS) is a rare and aggressive tumor in cats, usually presenting in a multicentric or disseminated form, with gastrointestinal involvement mainly reported as part of a metastatic disease. This report describes the first documented case of a primary intestinal HS in an 11-year-old male neutered domestic short-haired cat, presenting with acute gastrointestinal signs. Diagnostic workup included ultrasonography, cytology, histopathology, and immunohistochemistry (IHC), which confirmed a histiocytic origin through Iba-1, CD204 and MHC-II positivity and MUM1, CD117 and Desmin negativity. The patient underwent surgical excision via enterectomy, followed by adjuvant lomustine chemotherapy, achieving complete remission. Despite transient chemotherapy-induced myelosuppression, the cat remains alive and disease-free 2 years after diagnosis. This case highlights the importance of combining imaging, histopathology, and IHC when diagnosing feline intestinal masses.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41585534/