Peer-reviewed veterinary case report
Cat with rare primary intestinal histiocytic sarcoma and treatment
By Andrea Pérez et al.·Published in Frontiers in Veterinary Science·2026·AniCura Ars Veterinaria Hospital Veterinari, Barcelona, Spain, CH·View original on DOAJ →
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Original publication title: Case Report: Primary intestinal histiocytic sarcoma in a cat
- Species:
- cat
Plain-English summary
An 11-year-old male neutered domestic short-haired cat was brought in with sudden gastrointestinal issues, including vomiting and diarrhea. After a thorough examination, including ultrasound and tissue tests, the vet diagnosed a rare tumor called primary intestinal histiocytic sarcoma. The cat underwent surgery to remove the affected part of the intestine and received chemotherapy afterward. Thankfully, the treatment was successful, and the cat has been healthy and free of disease for two years since the diagnosis.
People also search for: cat vomiting and diarrhea · cat intestinal tumor treatment · feline histiocytic sarcoma · cat chemotherapy side effects · cat surgery recovery time
Abstract
Histiocytic sarcoma (HS) is a rare and aggressive tumor in cats, usually presenting in a multicentric or disseminated form, with gastrointestinal involvement mainly reported as part of a metastatic disease. This report describes the first documented case of a primary intestinal HS in an 11-year-old male neutered domestic short-haired cat, presenting with acute gastrointestinal signs. Diagnostic workup included ultrasonography, cytology, histopathology, and immunohistochemistry (IHC), which confirmed a histiocytic origin through Iba-1, CD204 and MHC-II positivity and MUM1, CD117 and Desmin negativity. The patient underwent surgical excision via enterectomy, followed by adjuvant lomustine chemotherapy, achieving complete remission. Despite transient chemotherapy-induced myelosuppression, the cat remains alive and disease-free 2 years after diagnosis. This case highlights the importance of combining imaging, histopathology, and IHC when diagnosing feline intestinal masses.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2025.1727437