Peer-reviewed veterinary case report
Dog with large mouth and neck mass like human plasmablastic lymphoma
By Giuliano, Antonio et al.·Published in Frontiers in veterinary science·2023·City University of Hong Kong, China·View original on PubMed →
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Original publication title: Case report: Suspected plasmablastic lymphoma in a dog resembling the clinical presentation in humans.
- Species:
- dog
Plain-English summary
A 7-year-old Mongrel dog was brought to the vet with a large mass in its mouth and neck. Tests showed that the mass was likely a type of cancer called plasmablastic lymphoma, which is rare in dogs. The vet used special staining techniques to confirm the diagnosis. Unfortunately, this type of lymphoma can be aggressive, and treatment options may vary. It's important for pet owners to discuss the best course of action with their veterinarian if they notice similar symptoms in their pets.
People also search for: dog mouth mass · dog neck swelling · plasmablastic lymphoma treatment · dog cancer symptoms · what to do if my dog has a tumor
Abstract
Plasmablastic lymphoma (PBL) is a rare form of lymphoma in people. PBL originates from plasmablasts and usually presents with swelling/mass in the mouth/neck. A 7-year-old Mongrel dog was presented for a large oral and neck mass. Cytology and histopathology were suggestive of a round cell tumor that was suspected to be lymphoma. An immunohistochemical (IHC) stain panel showed positive for CD18, thus supporting the diagnosis of round cell tumor, but negative for T- and B-cell lymphomas, CD3, CD20, and PAX-5. Other markers including cytokeratin AE1/3 (for epithelial cell origin), CD31 (for endothelial cells), SOX10 (for melanoma), IBa-1 (for histiocytic sarcoma), and CD117 (for mast cell tumor) were all negative. MUM-1 (for plasma cell differentiation) was strongly positive and CD79a (B cell and plasma cells) was also scantly positive. Based on the histopathology and immunohistochemistry results in combination with the clinical presentation, a suspected diagnosis of PBL was made. As per available literature, this is perhaps the first highly suspected case of PBL in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36875999/